Amino acid sequence information alone often fails to allow important function information to be identified in a significant fraction of genome sequences. Incorporation of three-dimensional structural information can produce significantly more and higher quality function annotations. This realization has resulted in the current focus on structural proteomics projects.

We present a structure-based function assignment method that improves both the yield and quality of functional annotations in whole or partial proteome analyses. Our structure-based method sheds biological insight not otherwise provided by sequence-only function prediction methods. This methodology forms the basis of our integrated platform in structural proteomics. The DIAMOND™ platform includes in silico functional analysis and structure and function confirmation by NMR spectroscopy.