Keynote
Keynote: Saccharomyces cerevisiae - Some Assembly Required
Christopher Hogue, Ph.D., Senior Scientist, Bioinformatics, Samuel Lunenfeld Research Institute
Track: Keynote
Date: Wednesday, January 30
Time: 1:00pm
- 1:45pm
Location: Canyon II
The Biomolecular Interaction Network Database, BIND is the fastest
growing database in Bioinformatics. A torrent of new information from
the yeast model organism has been added thanks to two large scale
experiments in mass spectromety published in the Jan 12 2002 issue of
Nature. The combined dataset of all known yeast interactions together
with a new complex-finding algorithm recently published in the Jan 11
2002 issue of Science, gives a compelling glimpse of the overall
structure of the eucaryotic nucleolus, the large nuclear organelle that
assembles ribosomes, and is one of the largest structures in a
eucaryotic cell. The BIND database sits atop significant infrastructure
in Bioinformatics including the NCBI data model, an integrated database
called SeqHound and high-performance cluster computing to compute
protein sequence neighbors. An overview of the new scientific results
obtained by combining this data together over the past two weeks will be
presented as well the global synthesis of molecular assembly information
and the underlying architecture of the BIND system.