Process Biology: integrated genomics and bioinformatics tools for improved target assessment
By Sittichoke Saisanit
Principal Scientist, Hoffmann-La Roche Inc.
With the availability of the human genome sequence, the number of potential drug targets has increased greatly in recent years. As a result, the way targets are assessed has become increasingly critical to the success of the drug discovery process. Unfortunately, the traditional methods relied on by the pharmaceutical industry to identify and validate targets is too slow and labor-intensive to be of use in the current environment. The solution to this dilemma is to adopt a new paradigm, which we term Process Biology. Process Biology integrates genomics and bioinformatics tools into automated, optimized modules that can be readily applied to a wide range of biological questions. By using organizational principles not usually applied to biological experiments, Process Biology can significantly impact target assessment and assist in decision-making throughout the drug discovery process.